The 49ers will be missing some of their top players for the NFC West opener at SoFi Stadium against the Rams: Christian McCaffrey (calf/Achilles tendon); Deebo Samuel (calf); George Kittle (thigh).

One former All-Pro does return to San Francisco's lineup, however: safety Talanoa Hufanga, who tore his ACL last November and will play for the first time since then on Sunday. Nick Bosa and Charvarius Ward were also questionable this week but are active on Sunday.

The Rams are also without key players, with star wideouts Cooper Kupp and Puka Nacua both out; Nacua is on the injured list with a knee injury sustained in Week 1, while Kupp is out with an ankle injury sustained last week. Los Angeles already has five offensive linemen on the injured list.