Bill's plot to watch: It may only be Week 5, but the Bills' defense is already dealing with a number of challenges, most recently Von Miller's four-game suspension this week. While middle linebacker Terrel Bernard (pectoral muscle) has a good chance of getting back on the field after missing two games, Buffalo will likely see rookie safety Cole Bishop make his first NFL start – Taylor Rapp is in the concussion protocol – and rookie Javon Without Miller, Solomon will see a larger role at stake. The Texans offense has a tough task ahead as QB CJ Stroud has thrown seven passing touchdowns and zero interceptions in his last five home games. — Alaina Getzenberg

Texans storyline to watch: Coach DeMeco Ryans said the Texans are “eager” for this matchup, but said his club won't get involved in the history of two AFC contenders. The Bills have the third-highest point differential in the NFL (plus-39) while the Texans are 24th (minus-15), showing the Bills have been more complete over the last four weeks. The Texans have three wins, but each victory was secured in the final minute after playing sloppy throughout. — DJ Bien Aime

Statistics you should know: If Josh Allen doesn't throw an interception, it will be the longest streak by a Buffalo quarterback to start a season in franchise history.

Bold prediction: Texas wide receiver Tank Dell has 85 receiving yards and one touchdown. I'm waiting for the Dell breakout game and it's coming. The second-year wideout still has a strong open score of 69 this season, a sign that his reduced production is more likely a result of increased target competition. — Walder

Fantasy X Factor: Texans running back Joe Mixon. Buffalo's defense is allowing the most fantasy points per game to running backs this season, making it a great matchup for Mixon. He has been rehabilitating from an ankle sprain for a few weeks and there was optimism that he could return after training in Week 4. Ultimately he was eliminated, but this matchup would be perfect for Mixon's return. — Moody

Betting nugget: Allen has a career ATS of 27-18-2 on the road (13-7-1 ATS as an underdog on the road).

Kahler's choice: Texans 27, Bills 21

Moody's selection: Bills 27, Texans 23

Walder's choice: Texans 27, Bills 24

FPI forecast: BUF, 56.0% (average 2.2 points)