In a season where injuries have been common, fantasy managers saw the loss of another top player on Thursday night. This time, 49ers running back Jordan Mason suffered a shoulder injury in the second quarter of a win over the Seahawks. He tried to return in the third quarter but only had one rush attempt before heading back to the sideline.

Mason did not return to competition.

49ers coach Kyle Shanahan made no comment on Mason after the game, but indicated more information on his status would be announced Friday.

“I don’t know, you never know,” Shanahan said. “I mean, the adrenaline levels are a little different these days during games. We’ll find out more tomorrow.”

Mason entered the game last night as one of the best running backs in fantasy football and an absolute gift from the fantasy gods. After all, he replaced the best running back in fantasy football, Chrisitan McCaffrey, who hasn't played a single snap this season due to Achilles tendon problems, and turned in an amazing performance.

The 49ers have a bye in Week 9, so it's possible Mason could miss the next two weeks and return in Week 10. But here's the problem… McCaffrey could reportedly be back even after the bye. In fact, SI NFL insider Albert Breer told Charissa Thompson before Thursday's game that McCaffrey “just started feeling like himself last week” and that the 49ers “will begin working him out in the last few days.” .

So, in a worst-case scenario for Mason, he could return as a replacement for CMC.

In the meantime, fantasy managers must submit a waiver claim for Isaac Guerendo. He had a solid performance in Mason's absence, running 10 times for 99 yards (9.9 YPC) and narrowly missing a touchdown. If Mason were to miss the next two weeks, Guerendo would be a solid RB2.