The White House is set to see another history-making vice presidential spouse.

With Ohio Senator JD Vance set to become the next vice president, his wife Usha Vance, the daughter of Indian immigrants, will be the first Indian-American second lady in the White House. She will also be the first Hindu second lady.

This follows Doug Emhoff's historic success as the first second gentleman in the White House. He is also the first Jewish person in this role.

JD Vance took to social media on Wednesday to thank “my wonderful wife for making this happen” after multiple news organizations, including ABC News, predicted that former President Donald Trump will win the presidential contest against Vice President Kamala Harris.

At 38, Usha Vance may be the youngest Second Lady since the Truman administration, when the then 38-year-old Jane Hadley Barkley, wife of former Vice President Alben Barkley, took over the role in 1949.

She grew up in a Hindu household in San Diego, where her parents are academics.

The Vances met while attending Yale Law School and married in Kentucky in 2014. They have three children together.

A lawyer who once clerked for Supreme Court Chief Justice John Roberts, she left her law firm, Munger, Tolles & Olsen after her husband was officially announced as the Republican Party's nominee for vice president to former President Donald Trump in July.

Usha Vance was in the spotlight at the Republican National Convention, where she introduced her husband.

“My background is very different than JD’s. “I grew up in San Diego, in a middle-class community with two loving parents, both immigrants from India, and a wonderful sister,” she said at the convention. “The fact that JD and I were even able to meet, let alone fall in love and get married, is a testament to this great country.”

She has since taken on a behind-the-scenes role in the campaign and has not spoken at a public campaign event since the RNC.

“Obviously I was asked at the convention to introduce JD and that was an active role,” she told NBC News in October. “But the thing that JD asked for, and the thing that I definitely agreed to, is to keep him company.”

She told NBC News at the time that she hadn't given much thought to what causes or initiatives she might focus on if she became second lady.

“You know, this is such an intense and busy experience that I haven't given much thought to my own roles and responsibilities,” she said.

“And so I thought, what should I do? See what happens on November 5th, gather some information yourself and take it from there,” she said. “There are certainly things that interest me, but I don’t really know how it all fits into this role.”

In her first interview after JD Vance was named Trump's running mate, Usha Vance discussed with “Fox & Friends,” how she and her husband share different political views, and suggested that their opinions influence each other in a “nice give and take.”

“I mean, we are two different people. We have a lot of different backgrounds and interests and things like that, so we come to different conclusions all the time,” she said. “That’s part of the fun of getting married.”

She was also asked to respond to her husband's widely criticized “childless cat lady” comment directed at Harris and others in a recently resurfaced 2021 Fox News interview.

“He made a joke to make it clear that he wanted to express something important,” she said. “And I just wish sometimes that people would talk about these things and that we would spend a lot less time going over this or that three-word phrase.”

She said, “Fox & Friends,” that she never thought she would go into politics, that they planned to become lawyers and have a family, and that they had agreed to keep their children out of the spotlight.

“We had a lot of serious conversations during his run for Senate, because we have three children, and giving them a stable, normal, happy life and a stable upbringing is the most important thing for us,” she said.