Oregon had two Big Ten games to welcome the conference, but this weekend's showdown against the Ohio State Buckeyes will be its biggest challenge yet.

Can QB Dillon Gabriel and the Ducks continue their success and improve to 6-0? Or will the Buckeyes remain undefeated as they travel to Autzen Stadium in one of the most anticipated games of the year?

Oregon vs Ohio State prediction and best bets

• Ohio State -3 (-110 at Fanatics Sportsbook)
• Overall first quarter score above 10.5 (+100 at BetMGM Sportsbook)
• Both teams score more than 20 points: Yes (-180 at DraftKings Sportsbook)

Although the Ducks are one of the top teams in college football, the Buckeyes appear to be one of the few teams that are better. With a dominant rushing attack featuring RB Quinshon Judkins and TreVeyon Henderson, Ohio State's offense should be able to sustain its attacks and win the battle for time of possession.

Oregon's close game against Boise State sticks out in my mind as the Broncos managed to break through the Ducks' run defense, resulting in a 37-34 barnburner. While Oregon will likely come out with better focus and motivation, it may not have as much luck against a talented Ohio State team.

Both teams have posted first quarter results in each of their first five games. Regardless of whether it comes from one side or both sides, the teams share the power. There should be some first points scored in this game and BetMGM is offering odds of +100.

From there, a transition to both programs that eventually exceeds the 20-point mark seems feasible. During slow grudge games or high-scoring affairs, both offenses have what it takes to remain efficient. It should stay that way on Saturday too.

Ohio State vs. Oregon CFB Week 7 odds

The Ducks enter this game as underdogs as sportsbooks favor Ohio State in this game by 3 to 3.5 points depending on the platform.

If you bet straight on the winner, Oregon's money line is between +125 and +140, while Ohio State's is between -150 and -165.

The over/under for the game is set at 54 or 54.5 depending on the platform.

Ohio State vs. Oregon moneyline odds analysis

Why Ohio State could be the favorite to win

Best odds: -150 Moneyline at Fanatics Sportsbook

When it comes to the Buckeyes, there may not be a more talented roster in all of college football.

After a disappointing 2023 season, many projected NFL picks decided to return with the motivation and intent of winning a championship this season. With QB Will Howard, RB Quinshon Judkins, S Caleb Downs and WR Jeremiah Smith on the roster, the team is full.

On both sides of the football, the trenches are very impressive, whether it's the offensive line giving playmakers time to capitalize or their front seven generating pressure and suffocating teams to an FBS-low 202.4 yards per game .

This Ohio State team has everything and should play in their favor this weekend.

Why Oregon could win as an underdog

Best odds: +140 Moneyline at Caesars Sportsbook

The big factor working in Oregon's favor heading into Saturday's game is Gabriel. While the passer may not be as flashy or athletic as some of the biggest names in college football, his efficiency is built to win close games.

Oregon has weapons including WR Tez Johnson, WR Evan Stewart and TE Terrance Ferguson. Everyone has the potential to improve the game on every route, which can help the game move in their favor.

Additionally, Oregon's pass defense is impressive. Opposing quarterbacks complete 53.4% ​​of passes against the Ducks. The Ducks' defense could help keep the Buckeyes' offense out of rhythm and give Oregon chances to pull off an upset at home.