This week's NFL action begins with the San Francisco 49ers hosting the Seattle Seahawks on “Thursday Night Football” (8:15 p.m. ET, Prime Video).

Despite their 2-3 start, the 49ers remain the favorite to win the NFC West (-115) ahead of the Seahawks (+225), who are atop the division at 3-2.

San Francisco has the best odds of any NFC team to win the Super Bowl (+750), tied for second overall with the Baltimore Ravens and trailing only the reigning champion Kansas City Chiefs (+450). The Seahawks are 40-1.

The odds for Thursday's matchup are unchanged at 49ers -3.5, but the total has been bet at 49.5 on ESPN BET from 46.5 at the start. ESPN's Football Power Index favors the 49ers at 4.6, with a 61.9% chance of an overall win.

Odds are current as of publication, courtesy of ESPN BET

Game lines

Spread: 49ers -3.5
Money line: 49ers (-185), Seahawks (+155)
Over/Under: 49.5

Distribution in the first half: 49ers -2.5 (-120), Seahawks +2.5 (-110)
49ers total points: 26.5 (above -120/below -110)
Seahawks total points: 22.5 (above -115/below -115)

The props

Passing by

Brock Purdy's total passing yards: 249.5 (Over -115/Under -115)
Purdy's total passing TDs: 1.5 (above -135/below +105)
Geno Smith total passing yards: 249.5 (Over -115/Under -115)
Smith's total passing TDs: 1.5 (Over +100/Under -130)

Rush

Jordan Mason total rushing yards: 79.5 (above -105/below -125)
Kenneth Walker III's total rushing yards: 59.5 (Over -135/Under +105)
Zach Charbonnet Total Rushing Yards: 14.5 (above -120/below -110)

Reception

Brandon Aiyuk total receiving yards: 69.5 (Over +105/Under -135)
Deebo Samuel Sr. total receiving yards: 59.5 (Over +105/Under -135)
DK Metcalf total receiving yards: 59.5 (Over -135/Under +105)
George Kittle's total receiving yards: 49.5 (above -110/below -120)
Jaxon Smith-Njigba total receiving yards: 44.5 (above -130/below +100)
Tyler Lockett total receiving yards: 44.5 (above -115/below -115)
Jauan Jennings total receiving yards: 29.5 (above -105/below -125)
Noah Fant total receiving yards: 24.5 (Over +105/Under -135)
Walker's total receiving yards: 19.5 (above -135/below +105)

The choice of Anita Marks

play

Who can bounce back on Thursday: 49ers or Seahawks?

Marcus Spears previews Thursday night's Week 6 matchup between the 49ers and Seahawks.

49ers -3 (-135 after buying half a point)

The 49ers have won five straight games overall against the Seahawks and are 4-0 against them (including playoffs), with Brock Purdy under center. Seattle posted a 3-0 record to start the season and faced quarterbacks such as Bo Nix (Denver), Jacoby Brissett (New England), Skylar Thompson and Tim Boyle (Miami). The Seahawks won't have that luxury against Purdy. Seattle, which has lost two straight, is playing its third game in 11 days and has a short week after a physical game against the Giants. Not to mention defensive injuries as well as ball loss and penalty problems. The 49ers are rolling here.

Betting trends

Courtesy of ESPN Stats & Info

• Seattle is 1-4 ATS this season, making it the worst in the NFL. The overs are 4-1 in Seahawks games.

• The 49ers have won five straight meetings (including playoffs) and were 4-1 ATS. The Seahawks are 18-9 ATS in their last 27 meetings (including playoffs).

• The Seahawks are 17-6 ATS as home underdogs since 2011, including 4-2 ATS in Geno Smith's starts. Smith is 9-4 ATS (3-10 overall) in primetime games.

• Over the last five seasons, teams that were at least 7-point favorites to lose have gone 37-25 ATS (.597) in their next games, including 4-1 ATS this year and 13-6 ATS in the last five seasons last two seasons. The 49ers lost at home as touchdown favorites to the Cardinals last Sunday.

• Brock Purdy was favored in all 26 regular-season starts this week, the longest streak to start a career in the Super Bowl era. He has an ATS of 7-1 when scoring fewer than four points.

• Home underdogs in Thursday games are 10-16 ATS since 2020.

More from ESPN